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The interactions of cobalt(II) with mitochondria from rat liver

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Abstract

The interactions of Co2+ with mitochondria have been investigated. The results indicate that Co2+ inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP.

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Authors and Affiliations

  1. Dipartimento di Scienze Ambientali, Università Cà Foscari, Venezia DD 2137, 30123, Venice, Italy

    Marcantonio Bragadin & Sabrina Manente

  2. Dipartimento di Chimica Biologica, Università di Padova e Centro Studio delle Biomembrane, C.N.R. Padova, Viale G. Colombo 3, 35121, Padua, Italy

    Antonio Toninello & Mario Mancon

Authors
  1. Marcantonio Bragadin
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  2. Antonio Toninello
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  3. Mario Mancon
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  4. Sabrina Manente
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Correspondence to Marcantonio Bragadin.

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Bragadin, M., Toninello, A., Mancon, M. et al. The interactions of cobalt(II) with mitochondria from rat liver. J Biol Inorg Chem 12, 631–635 (2007). https://doi.org/10.1007/s00775-007-0222-1

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  • DOI: https://doi.org/10.1007/s00775-007-0222-1

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