Dual red-NIR luminescent Eusingle bondYb heterolanthanide nanoparticles as promising basis for cellular imaging and sensing

https://doi.org/10.1016/j.msec.2019.110057Get rights and content

Highlights

  • Co-precipitation of Lncomplexes produces Eusingle bondEu, Eusingle bondYb and Ybsingle bondLu cores.

  • L-by-L deposition of PSS onto the cores results in hydrophilic colloid-stable NPs.

  • Eu → Eu and Eu → Yb energy transfer affects both red- and NIR-luminescence in the NPs.

  • Eusingle bondEu-Yb NPs exhibit dual sensing of lomefoloxacin by both Eu- and Yb-luminescence.

  • Efficient cellular uptake and low cytotoxicity of the red-NIR luminescent Eusingle bondEu-Yb NPs.

Abstract

The present work introduces ternary Ln(III) (Ln = Eu, Yb, Lu) complexes with thenoyltriflouro1,3-diketonate (TTA) and phosphine oxide derivative (PhO) as building blocks for core-shell nanoparticles with both Eu(III)- or Yb(III)-centered luminescence and the dual Eu(III)-Yb(III)-centered luminescence. Solvent-mediated self-assembly of the complexes is presented herein as the procedure for formation of Eusingle bondLu, Eusingle bondYb and Ybsingle bondLu heterometallic or homometallic cores coated by hydrophilic polystyrenesulfonate-based shells. Steady state and time resolved Eu-centered luminescence in homolanthanide and heterolanthanide Eusingle bondLu and Eusingle bondYb cores is affected by Eu → Eu and Eu → Yb energy transfer due to a close proximity of the lanthanide blocks within the core of nanoparticles. The Eu → Yb energy transfer is highlighted to be the reason for the enhancement of the NIR Yb-centered luminescence. Efficient cellular uptake, low cytotoxicity towards normal and cancer cells, and sensing ability of Eusingle bondYb nanoparticles on lomefloxacin additives via both red and NIR channels make them promising as cellular imaging agents and sensors.

Keywords

Mixed ligand complexes
Heterolanthanide nanoparticles
Dual luminescence
Energy transfer
Cellular imaging
Sensors
Fluoroquinolones

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