Issue 3, 2013

Water enhanced synthesis of gem-bisphosphonates via Rh(i) mediated 1,4-conjugate addition of aryl boronic acids to vinylidenebisphosphonate esters

Abstract

A new synthetic method characterized by low environmental impact for the synthesis of a wide range of gem-bisphosphonates bearing aryl substituents in β position as potential anti-resorption species to contrast osteoporosis is reported. The pivotal role played by water ensures higher yields compared to the organic medium in the rhodium-catalyzed 1,4-conjugate addition of arylboronic acids to vinylidenebisphosphonate tetraethylester, as well as easy product isolation.

Graphical abstract: Water enhanced synthesis of gem-bisphosphonates via Rh(i) mediated 1,4-conjugate addition of aryl boronic acids to vinylidenebisphosphonate esters

Supplementary files

Article information

Article type
Paper
Submitted
13 Nov 2012
Accepted
16 Dec 2012
First published
17 Dec 2012

Green Chem., 2013,15, 656-662

Water enhanced synthesis of gem-bisphosphonates via Rh(I) mediated 1,4-conjugate addition of aryl boronic acids to vinylidenebisphosphonate esters

G. Bianchini, A. Scarso, A. Chiminazzo, L. Sperni and G. Strukul, Green Chem., 2013, 15, 656 DOI: 10.1039/C2GC36800E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements