Issue 3, 2015

Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

Abstract

Micellar media in water provide a simple and efficient environment favoring the multi-component synthesis of 1,2,3-triazoles from organic bromides, sodium azide and terminal alkynes in the presence of [Cu(IMes)Cl] 1 catalyst at room temperature within a few hours. The micellar medium favors both the in situ formation of the organic azide and its metal promoted cycloaddition with the alkyne.

Graphical abstract: Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

Supplementary files

Article information

Article type
Communication
Submitted
17 Nov 2014
Accepted
11 Jan 2015
First published
13 Jan 2015

Green Chem., 2015,17, 1414-1422

Author version available

Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

E. Tasca, G. La Sorella, L. Sperni, G. Strukul and A. Scarso, Green Chem., 2015, 17, 1414 DOI: 10.1039/C4GC02248C

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