SCHEDULED MAINTENANCE
A simple synthetic entryway into new families of NHC–gold-amido complexes and their in vitro antitumor activity†
Ekaterina A.
Martynova, 
a
Min
Peng,
a
Kristof
Van Hecke,
a
Flavio
Rizzolio
bc
and
Steven P.
Nolan
*a
a
Min
Peng,
a
Kristof
Van Hecke,
a
Flavio
Rizzolio
bc
and
Steven P.
Nolan
*a
Abstract
A simple synthetic pathway to Au–NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NR1R2)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells.
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